Yahoo Sports Tennessee Titans 2025 game-by-game predictions following schedule release

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The 2025 NFL schedule has finally been released. Before its release, all we knew was who the Tennessee Titans' opponents would be and if they would face them at home or on the road. Now, though, we know the actual order of the games, and Brian Callahan can solidify his game plan for the year.

Knowing who each team's opponents were allowed analysts to determine the strength of schedule based on 2024 outcomes. With that information, we already know the Titans have one of the easiest schedules in 2025. Last year, the Washington Commanders found themselves in a similar situation with Jayden Daniels, and he took them to the NFC Championship Game.

Now, we're not piling on expectations for Cam Ward, but he certainly has a similar opportunity in 2025. We'll just have to see if Callahan and Ward can combine to make a similar kind of magic as Dan Quinn and Daniels.

All of that said, let's go through each game the Titans will play in 2025 and attempt to predict the outcomes.

Week 1: at Denver Broncos, Sunday, Sept. 7 at 4:05 p.m.​


This will mark the fourth time in six years that the Titans and Broncos have met during the regular season. This year, Cam Ward will make his NFL debut at Mile High Stadium on September 7 at 4:05 p.m. ET, airing on FOX. Mile High Stadium is a tough place to play, and while Ward is no stranger to adversity, it's unlikely the Titans walk away with a win.

Score prediction: Broncos 21, Titans 17

Week 2: vs. Los Angeles Rams, Sunday, Sept. 14 at 4:05 p.m.​


The Rams were 10-7 last season, losing in the divisional round of the playoffs. They're a consistent team with talented enough pieces to go on the road and win games. The Titans lose this one.

Score prediction: Rams 24, Titans 20

Week 3: vs. Indianapolis Colts, Sunday, Sept. 21 at 1:00 p.m.​


The Titans fell to the Colts both times they met last season, but the Titans are on a mission in 2025. Cam Ward is already impacting the organization off the field, and it's not going to stop there. Titans win at home.

Score prediction: Colts 13, Titans 17

Week 4: at Houston Texans, Sunday, Sept. 28 at 1:00 p.m.​


Coming off of a divisional win over the Colts, the Titans will ride that momentum into Houston. It will be a tough game, tight until the end, but the Texans come out on top at home.

Score prediction: Texans 21, Titans 20

Week 5: at Arizona Cardinals, Sunday, October 5 at 4:05 p.m.​


The Cardinals have been quiet in recent years, even with Kyler Murray under center, they haven't been as dominant as many thought they would be. They made some key additions this offseason to bolster their defense, but their offense remains largely the same. Cam Ward lights a fire under the Titans in this one, and they get the win.

Score prediction: Cardinals 17, Titans 24

Week 6: at Las Vegas Raiders, Sunday, October 12 at 4:05 p.m.​


The bright lights of Las Vegas, a new head coach in Pete Carroll, a superstar rookie running back in Ashton Jeanty, and a road game. The Titans might surprise us with a win, but it's more likely the Raiders come out on top.

Score prediction: Raiders 18, Titans 14

Week 7: vs. New England Patriots, Sunday, October 19 at 1:00 p.m.​


The Titans host their former head coach, Mike Vrabel when they face the Patriots. It will be the first time Vrabel has been on the opposite sideline since he was fired in 2023. The Patriots have struggled mightily since the departure of Bill Belichick, but this isn't Vrabel's first rodeo. Patriots win in Nashville.

Score prediction: Patriots 24, Titans 21

Week 8: at Indianapolis Colts, Sunday, October 26 at 4:05 p.m.​


The Colts have to find their footing at some point and get some wins. The Titans aren't going to win all of their divisional games, and this is one they'll struggle in. Colts win this one.

Score prediction: Colts 20, Titans 17

Week 9: vs. Los Angeles Chargers, Sunday, November 2 at 4:25 p.m.​


With Will Levis under center against the Chargers in 2024, the Titans lost 27-17 in Jim Harbaugh's first year as head coach. This year, Cam Ward will be under center with a stronger offensive line, more weapons on offense, and a defense that's been solidified. It will be close, but the Titans win.

Score prediction: Chargers 14, Titans 15

Week 10: BYE​

Week 11: vs. Houston Texans, Sunday, November 16 at 1:00 p.m.​


The Titans and Texans have a deep rivalry that makes predicting the outcomes of their games difficult. They've split their last 10 meetings 5-5 over five years, and where they play doesn't seem to matter. This year, though, Cam Ward will be most comfortable at home in his rookie season. Titans get the nod.

Score prediction: Texans 20, Titans 28

Week 12: vs. Seattle Seahawks, Sunday, November 23 at 1:00 p.m.​


The Seahawks saw a lot of change this offseason, and not all of it was good, but the Titans historically have struggled against the Seahawks, winning just eight of 19 matchups. Still, this is a new-look Seahawks team and a new-look Titans team that includes former Seattle Seahawk Tyler Lockett. Titans get the victory.

Score prediction: Seahawks 17, Titans 20

Week 13: vs. Jacksonville Jaguars, Sunday, Nov. 30 at 1:00 p.m.​


The Titans lost both of their games to the Jaguars in 2024, even the second meeting of the season when Trevor Lawrence was injured. They won't want to see that happen again, especially the defense. Titans win.

Score prediction: Jaguars 13, Titans 20

Week 14: at Cleveland Browns, Sunday, December 7 at 1:00 p.m.​


It's really going to depend on who the quarterback is in Cleveland in 2025 to truly predict an outcome of this matchup. The Browns seem to always be in bad situations with their players, and currently carrying five quarterbacks shows how bad that situation is. The Titans should have no problem dispatching the Browns.

Score prediction: Browns 10, Titans 24

Week 15: at San Francisco 49ers, Sunday, Dec. 14 at 4:25 p.m. ET​


Historically, the 49ers have posed a problem for the Titans. Out of their 15 meetings, the Niners have won nine of them. They made some changes during free agency and through the draft, but only won six games in 2024. It's a long trip for the Titans, but they get the win on the road.

Score Prediction: 49ers 18, Titans 20

Week 16: vs. Kansas City Chiefs, Sunday, Dec. 21 at 1:00 p.m.​


The Chiefs have appeared in five of the last six Super Bowls, winning three of them. The Titans and Chiefs haven't met since 2022, and both teams are very different today than they were then. At Nissan Stadium, where the Titans and Cam Ward will be most comfortable, it's going to be a hard-fought game that no one expects.

Score prediction: Chiefs 28, Titans 20

Week 17: at Jacksonville Jaguars, Sat/Sun TBD​


The Titans lost to the Jags twice last year. Predicting them to defeat their division rival at home is one thing, but in hostile territory? Actually, yes. The Titans beat the Jags on the road this year and end the regular season on a high note.

Score prediction: Jaguars 10, Titans 14

This article originally appeared on Titans Wire: Titans 2025 game-by-game predictions following schedule release

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